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Oral bioavailability is limited due to enzymatic breakdown in the gastrointestinal tract, yet some studies show systemic benefit at doses of 5001500 mg daily

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Resources We Trust Mayo Clinic: Psoriasis Cleveland Clinic: Rheumatoid Arthritis National Institutes of Health: Autoimmune Diseases American Academy of Dermatology Association: Psoriasis: Causes Arthritis Foundation: Understanding Rheumatoid Arthritis Flares Martin A et al