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Results from the Phase 2 trials showed clear dose-dependent effects, with higher doses of cagrilintide producing greater weight loss when combined with semaglutide

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GLP-1 Agonists (Semaglutide, Tirzepatide) These compounds have FDA-approved versions (Ozempic, Mounjaro) with extensive safety and efficacy data from large clinical trials

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Although glucagon action is primarily liver specific, glucagon receptors have been reported to be present in membranes of human adipose tissue (83), suggesting that direct action of glucagon likely plays an important role in regulating human, as well as rodent, lipolysis