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Administering high doses of biotin (23 mg/kg/d) and thiamine (100300 mg/d) shortly after symptoms onset can lead to complete resolution or remission of symptoms within a few days in the majority of patients

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Additionally, evening dosing may be more convenient for individuals with busy morning schedules or those who prefer to administer injections in the privacy of their home after work

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That excess pigment clusters and rises to the surface, leaving behind a flat, darkened patch