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In OA cartilage tissues and IL-1stimulated chondrocyte models, iron accumulation, elevated levels of lipid peroxidation byproducts such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), and downregulation of the antioxidant enzyme GPX4 have been widely reported (5153)

These interventions work best when combined with active rehabilitation rather than used in isolation

Furthermore, this study also investigates the environmental and biological implications of these interactions, suggesting promising paths for future research and technological applications that combine sustainability and innovation in materials engineering

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Kokrashvili Z, Mosinger B, Margolskee RF