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How Much Weight Loss Do GLP-1 Drugs Produce Across the three reviews, tirzepatide (Mounjaro and Zepbound), semaglutide (Ozempic, Wegovy, and Rybelsus), and liraglutide (Victoza and Saxenda) all led to notable weight loss over one to two years compared with placebo

At higher doses, you go through vials faster, but waste is minimal

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