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A significant proportion of the cytochrome c in the mitochondria seems to be associated with cardiolipin, involving two major mechanisms
TMAO, generated from microbial metabolism of dietary precursors such as phosphatidylcholine and carnitine, directly promotes atherogenesis by activating inflammatory pathways and disrupting lipid metabolism [32]
Previous studies have elucidated that AGE-RAGE pathway can affect bone homeostasis in multiple links, including biomineralization [57], osteogenesis [58], osteoclastic differentiation [59], etc
Among participants aged 75 years or older (n = 920), significant glycemic and weight reductions were also observed, although analyses of HbA1c and weight trajectory included smaller subgroups of 349 and 104 patients, respectively