The 10 mg dose of tirzepatide showed greater weight reduction versus semaglutide 1 mg by -1.8 mmHg (-3.4 to -0.1) while the 15 mg dose of tirzepatide reduced an additional -3 mmHg (-4.6 to -1.3) compared to semaglutide [65]
Patients should communicate openly about their tolerance for side effects, lifestyle factors that might influence medication choice, and their weight loss goals and timeline
For weight management, NICE technology appraisals TA875 (semaglutide/Wegovy) and TA664 (liraglutide/Saxenda) recommend these medications only within specialist weight management services for adults with a BMI 35 kg/m (or 32.5 kg/m in certain ethnic groups) with weight-related comorbidities, and under specific time-limited conditions
In this blog, well explore how GLP-1s may interact with PMDD (premenstrual dysphoric disorder), and how hormonal changes can affect hunger and cravings, potentially influencing weight management efforts
Dalsgaard NB, Gasbjerg LS, Hansen LS et al (2021) The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes