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The synergy between semaglutide's direct metabolic actions and the metabolic benefits of weight loss means that patients who achieve the greatest weight reductions tend to see the most dramatic lipid profile improvements

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Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN-6 retinopathy data)

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doi:10.1016/j.jacc.2022.01.038 30 Sandsdal RM et al.: Combination of exercise and GLP-1 receptor agonist treatment reduces severity of metabolic syndrome, abdominal obesity, and inflammation: a randomized controlled trial