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STEP-1 trial (Wilding et al., New England Journal of Medicine, 2021) primary clinical trial for semaglutide 2.4 mg (Wegovy), source for the cross-drug diarrhea-rate comparison

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Your healthcare provider may recommend diagnostic evaluation, including upper endoscopy (esophagogastroduodenoscopy) if you have alarm symptoms, refractory GERD despite optimized therapy, or risk factors for Barrett's esophagus (such as chronic GERD plus male sex, age over 50, White race, central obesity, tobacco history, or family history)

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