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Collectively, this study revealed that a signaling cascade comprising Src, PDK1, Akt, and ubiquitin-specific protease 33 (USP33) mediate arrestin deubiquitination and acute receptor desensitization by sequestering G in the nucleus

Clinical & experimental metastasis, 27(8), 601609

For ipamorelin, it referenced a study reporting serious adverse events, including death, when the peptide was given intravenously