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In the rat model, bidirectional effects on nitric oxide synthases have been observed: stimulation of the endothelial form (eNOS) with simultaneous inhibition of the inducible form (iNOS), suggesting a role in maintaining vascular homeostasis

Human clinical trial data remains the weak link across every application

Sources : WHO International Programme on Chemical Safety

The gut-brain axis, gut-immune axis, and gut-skin axis all suggest that improving intestinal health can produce cascading improvements throughout the body

In case of low bile acid absorption, FXR is not activated, FGF19 stays low and bile acid synthesis is stimulated