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Optic neuritis (from multiple sclerosis or other causes) Mechanism: Inflammation and demyelination of optic nerve, often associated with multiple sclerosis

it can cross the blood-brain barrier, leading to neuroinflammation

Limitations The study drew from a single large health system, which may affect how broadly the findings apply

It is possible that the blood lactate levels were lower because of the secondary role of L-carnitine balancing the acetyl-CoA/CoA ratio allowing pyruvate to be converted into acetyl-CoA instead of lactate (31), but this is unlikely due to the moderate intensity level when blood lactate was evaluated