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GMX1777 is a cyanoguanidine compound that is rapidly converted into the active form GMX1778, a competitive inhibitor of NAMPT

Thyroid dysfunction : An underactive thyroid slows metabolism significantly, making fat burning difficult even with appetite suppression in place

[DOI] [PubMed] [Google Scholar] 44.Jones DP, Go YM

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Table 12: Results at Week 24 (LOCF*) in an Active-Controlled Trial of Dapagliflozin Initial Combination Therapy with Metformin HCl Extended-Release in Adults with Type 2 Diabetes Mellitus Dapagliflozin Add-On To Metformin HCl Immediate-Release A total of 546 adult patients with type 2 diabetes mellitus with inadequate glycemic control (HbA1c 7% and 10%) participated in a 24-week, placebo-controlled trial to evaluate dapagliflozin in combination with metformin HCl (NCT00528879)