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Within cells (principally the liver where it is stored) the folic acid found in enriched food and in vitamin supplements is converted first to dihydrofolate (DHF) and then to tetrahydrofolate (THF also H 4 folate) through the action of dihydrofolate reductase, an NADPH-requiring enzyme

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First discovered in 1977 by Swiss researchers who isolated it from the cerebral venous blood of sleeping rabbits, DSIP was initially identified for its ability to promote delta-wave sleep when administered to various animal species