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Future therapies would ideally modify CSF secretion to control ICP but also induce weight loss

These secondary bile acids activate FXR receptors on the surface of the intestinal epithelium and immune cells, increase the expression of the intestinal epithelial tight junction and enhance intestinal barrier function

However, evaluation of the intestinal barrier in clinical studies is usually limited to the assessment of the paracellular permeability

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In this meta-analysis, the time span to the first occurrence of a confirmed MACE-4 (cardiovascular death, myocardial infarction, stroke, and hospitalized unstable angina) between study participants with T2D receiving tirzepatide was compared with the control groups receiving different standard therapy