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In the phase 2 diabetes trial, hepatic fat fraction measured by MRI-PDFF decreased by a mean of 73% from baseline in the 12 mg group compared with 14% in the placebo group [8]
Like the GLP-1, it also reduces gastric emptying but has the added effect of suppressing appetite in the hypothalamus
Some individuals may notice subtle changes in their skin tone within a few days, while others may not see visible results for a longer period
Clinical trials have shown that both medications can lead to significantly greater weight reduction compared to placebo, with average body weight changes ranging from 10% to 20% of initial weight
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10.1016/j.ejphar.2017.10.050 [DOI] [PubMed] [Google Scholar] 88.Zeng L, Lin L, Peng Y, Yuan D, Zhang S, Gong Z, et al
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