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Osteosarcoma frequently develops chemoresistance to these drugs through mechanisms involving increased DNA repair, drug efflux, and anti-apoptotic signaling, which leads to treatment failure and disease recurrence 84

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Continental's previous merger talks with Star Alliance founding partner United were viewed in some circles as a serious threat to Continental's future at Hopkins, and the planned merger with United prompted Cleveland area politicians to propose hearings to investigate the potential impact of the 2010 Continental-United merger on the community