retatrutide triple agonist weight loss trial Retatrutide, an Amazing Future for Mazdutide vs retatrutide: dual agonist

Treatment duration varies by individual

[DOI] [PubMed] [Google Scholar] 15.Perkovic V, et al

What sets retatrutide apart is its triple agonist approach, which means it acts on three hormone pathways in your body at the same time: GLP-1, GIP, and glucagon

33 Although decreases in gastric emptying via GLP-1RAs help prevent overnutrition by decreasing nutrient absorption, there is concern that patients could be at risk of nutrient deficiencies driven by malabsorption from delayed gastric emptying

The heart-rate cost is mostly the glucagon arm: GLP-1 on its own nudges heart rate up a little and then flattens, while glucagon carries the part that keeps climbing with the dose