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Some patients benefit from meal timing adjustmentseating larger breakfasts or lunches when appetite is strongest, and lighter dinnersto ensure consistent nutrition throughout the day

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We propose that liver-targeted TR agonists that are capable of uncoupling beneficial effects from deleterious effects could be tested in future clinical studies for the treatment of type 2 diabetes

This mechanism is currently being compared to mitochondrial uncoupling agents in various bioenergetic studies

On one side, you have a naturally occurring mitochondrial peptide with profound implications for cellular energy