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Proponents argue this maintains more stable tissue levels, though others find once-daily dosing equally effective with better compliance

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Because only one study focused on lithium, we conducted a sensitivity analysis to include only studies of N -acetylcysteine, using meta-regression to evaluate the following potential confounding factors: (1) mean age (years), (2) diagnosis (OCD or OCD-related disorders), (3) study duration (in weeks), (4) total number of individuals, and (5) percentage of female participants

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PloS One (2010) 5:e10817