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Optimal timing depends on your goal: Athletes : 30-60 minutes before training to maximize fat burning during exercise Weight loss outside of sports : morning intake on an empty stomach to optimize fat mobilization throughout the day Rest days : morning intake with breakfast L-carnitine is absorbed better with carbohydrates (insulin effect) orange juice or a fruit as accompaniment improves absorption

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Jangid, P., Malik, P., Singh, P., Sharma, M., & Gulia, A

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At the same time, reduced IDO activity reduced kynurenine and further weakened peripheral immune tolerance, which played a driving role in the hypothyroidism immune disorder caused by the imbalance of the whole gut microbiota (Clarke et al., 2017)