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In fibroblast cultures, GHK-Cu administration increases collagen synthesis by 70% while simultaneously enhancing collagen quality through improved cross-linking patterns

The knowledge of melatonin as an autophagy modulator derives mainly from HI studies 59,60,61,62

doi: 10.3389/fphar.2024.1491249 Received 04 September 2024 Accepted 14 November 2024 Published 02 December 2024 Volume 15 - 2024 Edited by Anna Maria Giudetti, University of Salento, Italy Reviewed by Daniele Vergara, University of Salento, Italy Azza Awad, Al-Azhar University, Egypt Updates Copyright 2024 Mahmoud, Elshazly, El-shaarawy, Zaitone, Aldahish, Ahmed, Fawzy, Aloyouni, Abed, Saeedi and El-Sayed

Additionally, Salviolone has been shown to inhibit cervical cancer cells by inducing autophagy and inhibiting the NF-B/mTOR/PI3K/AKT pathway [42]