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Orforglipron also is more likely to increase heart rate (by about 4 beats per minute)

This mechanism increases nitric oxide production, which is essential for endothelial cell proliferation, vessel dilation, and new capillary formation

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Brain Sciences (2021) This study by an independent research group (outside the original Washington State University team) demonstrated that Dihexa rescues cognitive impairment in an Alzheimer's disease mouse model (APP/PS1 transgenic mice)

As expected, silencing of endogenous KEAP1 increased luciferase activity driven by ARE elements under Cyss depletion conditions, whereas simultaneous expression of exogenous shRNA-resistant KEAP1 restored basal expression (Fig