116 As a p53 target gene, damage-regulated autophagy modulator (DRAM) is an effector of p53-mediated death and encodes a lysosomal protein that promotes autophagy
Moreover, betaine reduces hepatic triglyceride accumulation by lowering methylation of the PPAR promoter and enhancing PPAR expression, offering a promising approach to mitigating liver disease progression through the modulation of lipid metabolism (90)
It may help support fat breakdown, improve energy utilization, and contribute to weight management and appetite control when combined with a balanced diet and regular exercise
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