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The three main problems in relation to treatment with insulin secretagogues are Hypoglycemia Weight gain Cardiovascular risk (an open discussion to date) Contraindications for treatment with insulin secretagogues are as follows: Type 1 diabetes, pregnancy, major surgeries, infections, severe trauma, allergy predisposition, and severe hypoglycemia risks (Table 10.5)

A second injection for the same area with Lemon Bottle can be scheduled as early as the 8th day after the first, with a three-injection basic course taking less than a month