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Antioxidant Action of Ergothioneine: Assessment of its Ability to Scavenge Peroxynitrite

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Contributing factors may include B12 or folate deficiency (since methionine generation requires these nutrients), or excessive SAMe utilization in polyamine synthesis as part of a maladaptive chronic inflammatory response to tau pathology (10, 11)

Anesthesia was administered prior to drug injections to ensure animal comfort and minimize stress