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As for mortality, both SGLT-2 inhibitors and GLP-1RA are similar in reducing both total and CV deaths, but SGLT-2 inhibitors only are superior to DPP-4 inhibitors for both deaths, whereas GLP-1RA are superior to DPP-4 inhibitors for total death, but equal for CV death

The interaction between semaglutide and alcohol is another practical concern, as many users report increased alcohol sensitivity and reduced tolerance while on GLP-1 agonists

The result is a shift in satiety signaling : You feel fuller sooner

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The proposed mechanism most often cited involves GIP-receptor-mediated effects on adipose insulin sensitivity and possibly on central energy balance, though attribution between the two receptors in vivo remains an area of ongoing study