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Additionally, the closed structure of the knee joint and the absence of blood vessels in articular cartilage pose challenges for drugs to accumulate in the joint through the bloodstream

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It appears that AC can suppress MMP-1 expression in cultured human epidermal keratinocytes, an effect that is probably mediated by modulation of MAPK/AP-1 and I-/NF- signaling pathways (Gao et al

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