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When semaglutide is discontinued, appetite hormones gradually return to baseline over several weeks

Routes of Administration Subcutaneous injection (standard): Protocols describe injection in the abdomen, thigh, or upper arm, rotating sites between injections, using standard SC technique with a 29-31 gauge insulin syringe

This reactive transformation entails morphological, functional and transcriptional remodeling, forming a continuum of activation states ranging from transient, protective responses to chronic, neurotoxic phenotypes