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To prevent oxidative stress and the inflammatory response in acute and chronic progressive diseases, approaches to enhance the expression of Nrf2 and thereby inhibit ferroptosis should undoubtedly play a central role in treating ALI, COPD, and idiopathic PF in the future

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Clinical trials and observational studies have found that insufficient levels of serum 25(OH)D correlate with an increased risk of significant cognitive deterioration [79]

Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells