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Glutathione is often touted for its antioxidant, detoxification, and skin-brightening properties

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Studies have demonstrated that PHGDH overexpression enables breast cancer cells to redirect more glutamine into the tricarboxylic acid cycle via the SSP, thereby supporting rapid cell proliferation ( In addition, a synthetic lethal relationship exists between the oncogenic activity of IDH2 and the serine synthesis pathway in both TNBC and HER2-positive breast cancer, rendering cells with high IDH2 expression particularly sensitive to PHGDH or PSAT1 inhibition ( 4.2.2 Pancreatic cancer The tumor microenvironment of pancreatic cancer is nutrient-deficient, especially with regard to serine limitation