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& Swarup, V

Studies show that taking 1g L-citrulline plus 1g L-arginine together, produces higher plasma L-arginine concentrations than taking either supplement individually at double the dose

suggests that multiple amino acid substitutions are introduced to support the peptides stability against enzymatic degradation potentially: (1) Position 2 (Alanine D-Alanine): Introduces a D-form amino acid, which is less susceptible to standard enzymatic breakdown

Maier S, Nickel K, Lange T, Oeltzschner G, Dacko M, Endres D, Runge K, Schumann A, Domschke K, Rousos M, van Elst LT (2023) Increased cerebral lactate levels in adults with autism spectrum disorders compared to non-autistic controls: a magnetic resonance spectroscopy study

Regulatory authorities such as the U.S