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Both errors share the same root cause: treating microneedled skin like intact skin

Two experimental agents (dexamethasone and hydroxychloroquine) have shown some promise as treatment agents 62,183,207

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The presence of mucus on the gastrointestinal tract surface and other factors contribute to rapid drug loss and low diffusion efficiency, leading to poor therapeutic outcomes and reduced patient compliance

Analysis of the microbial composition revealed that metformin treatment increased the abundance of Firmicutes and decreased the abundances of Actinobacteria and Proteobacteria at the phylum level (Fig