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Departments of Agriculture and Health and Human Services | AAFP, accessed April 22, 2025, Healthy diet - World Health Organization (WHO), accessed April 22, 2025, 2015-2020 Dietary Guidelines for Americans - Office of the Assistant Secretary for Health, accessed April 22, 2025, Muscle Mass and Glucagon-Like Peptide-1 Receptor Agonists: Adaptive or Maladaptive Response to Weight Loss

Many people remain on starter doses that are intended only for tolerability, not therapeutic effect

The infusion itself is typically painless

Additionally, all included studies were RCTs, thereby reducing within-trial bias

The body composition case for ipamorelin is largely mechanistic: if you increase GH pulsatility without raising cortisol (which promotes fat storage), the net effect on body composition should be favorable