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Funding The research is financially supported by the Shuangchuang Ph.D award of Jiangsu Province (No.JSSCBS20211252), the initializing Fund of Xuzhou Medical University (No.D2020013), the National College Students of Innovation and Entrepreneurship Training Program in Jiangsu Province (No.202110313048Y) and the Natural Science Foundation of Jiangsu Higher Education Institutions of China (No.22KJB310021 and No.22KJB520040)