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Strengths and weaknesses of this review This systematic review and meta-analysis was registered and reported with PRISMA [21] and included the full of original trials whenever possible

Participants with obesity and pre-diabetes were prescribed subcutaneous liraglutide titrated from 0.6 mg to 3 mg once daily over two months [22]

SUSTAIN Trials The SUSTAIN clinical trial program evaluated the safety and efficacy of semaglutide in the treatment of type 2 diabetes

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