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CI-DME is defined as thickening within the central 1mm diameter or center subfield zone. 6 Staging retinopathy and DME offers an organized approach for management based upon risk of progression and ultimately, risk of vision loss

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Higher-potency formulations (semaglutide up to 2.4 mg and tirzepatide) were used, which may account for stronger weight effects compared to pediatric trials that employed lower doses

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