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FDA Approval Criteria: For FDA approval as weight loss medication, drugs must demonstrate: Efficacy Requirements: At least 5% average weight loss greater than placebo At least 35% of patients lose 5% body weight At least 15% of patients lose 10% body weight Safety Requirements: Acceptable safety profile in clinical trials Benefits outweigh risks Appropriate for long-term use All newer GLP-1 medications far exceed the minimum efficacy requirements, which explains their dominance

All animal procedures are followed and approved by Indiana University School of Medicine Animal Care and Use Committee

Nature 374 , 354356 (1995)

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