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It happens when the filler is injected too close to the skin surface

Following MTX injection (in physiological saline, 20 mg/kg, single dose), either saline (MTX group, n 8) or WPC (2 g/kg, oral gavage, MTX + WPC group

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Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy