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Furthermore, the included studies were heterogeneous concerning the characteristics of patients and study design (2 of studies on L-carnitine supplementation have been performed in the setting of hemodialysis when carnitine metabolism is altered in uremia and the depletion of carnitine is expected 62 , 4 in diabetic/metabolic syndrome patients with dyslipidemia and 1 in hyperlipidemic patients)

Proactive patient education on maintaining balanced micronutrient intake during GLP-1 RA therapy is critical to mitigate preventable complications

Patients with certain FTO variants often benefit from eating their main meal earlier in the day when metabolic flexibility is highest, which might suggest morning or mid-day injection timing for better meal-hormone synchronization

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Pain is a signal - not an enemy