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This is more common in longer cycles with LR3

Beyond sleep, DSIP research has revealed potential applications in pain management (showing analgesic effects when administered intracerebroventricularly), addiction treatment (alleviating withdrawal symptoms in 97% of opiate-dependent and 87% of alcohol-dependent patients in one trial), antioxidant defense, and even stroke recovery

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J Clin Endocr Metab 85:536-539, 2000 16a

Relevantly, gliT is regulated independently of the rest of the gli cluster, which allows gliotoxin biosynthesis and self-protection to function autonomously (Schrettl et al., 2010)