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In another rat model, fisetin treatment was shown to reduce oxidative stress, autophagy, apoptosis and inflammation in reserpine-induced FM

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12 Exendin (9-39), a GLP-1 receptor antagonist, and blockade of dipeptidyl peptidase-4 (DPP4), an enzyme responsible for GLP-1 degradation, did not nullify the decreased alcohol consumption and alcohol-seeking behaviors induced by liraglutide and semaglutide, signifying the lasting impact of the GLP-1 receptor agonists despite antagonistic influences

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