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290 , E317E325 (2006)

Who May Need Extra Caution Extra caution may be needed for patients who are pregnant or trying to become pregnant, have active cancer or a cancer history requiring specialist input, have autoimmune disease, have clotting concerns, use immune-modifying medication, have uncontrolled diabetes, have significant kidney or liver disease, or are scheduled for surgery

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Gastric Emptying Modulation Dual Pathway Effect Both components contribute to delayed gastric emptying through complementary mechanisms[5]: GLP3 delays gastric emptying primarily through GLP-1R and glucagon receptor pathways Cagrilintide slows gastric transit through amylin and calcitonin receptor activation Combined effects produce more sustained gastric delay than single agents Prolonged nutrient exposure in the small intestine enhances incretin release This dual-pathway gastric slowing mechanism may explain enhanced satiety and reduced caloric intake observed in combination studies