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In contrast, less atherosclerosis prone endothelium is exposed to laminar shear stress causing activation of signaling pathways that maintain endothelial cell coaxial alignment, proliferation, (13,14) glycocalyx layer, (15) and survival (12,16)

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IV antioxidant support (glutathione, vitamin C, NAD+ adjuncts) may be used as adjunctive measures to address oxidative stress in inflamed tissue, guided by biomarkers and clinical context

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Hence, further studies are needed to definitively determine the precise origin of the MUC5B + cell population