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Before taking a GLP-1 drug, you should be aware that there are some potential risks associated with these medications, including: Allergic reactions Bowel obstruction Gallbladder problems, including bile duct blockages and gallstones Low blood sugar (hypoglycemia), especially when the GLP-1 is taken with insulin or oral diabetes medications Muscle loss due to rapid weight loss Nutritional deficiencies due to changes in food absorption Pancreatitis (inflammation of the pancreas) Slower absorption of oral medications, which may lead to reduced effectiveness of oral contraceptives and other drugs Thyroid tumors To help reduce the risk of some of these side effects, consider the following tips: Consume adequate protein and fiber Consume smaller, more frequent meals Limit alcohol intake Avoid high-fat foods Who should not take GLP-1 medication

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Studies show around 18.3% body weight lost at 12 months and mean losses as high as 25.5% at 18 months for specific responders

doi: 10.1007/s13273016-00230 132 NasiriAZiamajidiNAbbasalipourkabirRGoodarziMTSaidijamMBehroujHet al

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications originally developed for managing type 2 diabetes