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Kitagawa H

a brain 18 F-FDG-PET study

The discovery of the G-proteincoupled estrogen receptor (GPER1) in the early 2000s provided insight into these non-genomic mechanisms ( in vivo role of GPER1 remains under debate ( Ligand-independent actions of estrogen receptors (ERs) have also been described, particularly in the uterus, where ER can be activated by growth factor pathways (e.g., IGF-1), leading to receptor recruitment to chromatin in the absence of estrogen binding (Figure 1)