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Metformin, the current first-line treatment in T2DM, has an unclear antidepressant effect [166] despite identified direct mechanisms and pleiotropic effects, including inhibition of angiotensin II and NF-B factor, normalization of gut microbiota, and intestinal permeabilization, and in vivo experimental data [167] supporting its potential benefits

27(12): 96772 Xia LJ, Folkers K

Effects of graded dietary gamma-aminobutyric acid levels on growth performance and stress responses under acute temperature exposures in rainbow trout (Oncorhynchus mykiss)

10.1016/j.biopha.2022.114175 [DOI] [PubMed] [Google Scholar] 264.Wen, L., Yang, H., Ma, L

FIGURE 3 3.6 Molecular docking Data in Table 3 reveal the binding energy of AFT (B1, B2, G1, and G2) to the SOD1, SOD2, GPx, GR, GCLC, and GSH synthase binding sites of Japanese quails