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The amount delivered by a single microinfusion session is roughly 5 percent of one day's dietary intake

Using this serum vitamin B 12 cut-off alone, the prevalence of vitamin B 12 deficiency is estimated to be in the range of 5% to 15%.3 4 5 6 However, when higher serum vitamin B 12 cut-off at 258 pmol/L (350 pg/mL) or using elevated serum homocysteine or MMA level in addition to a low or low-to-normal serum vitamin B 12 level to diagnose vitamin B 12 deficiency, the prevalence of deficiency increases to 40.5%.1 3 Also, the prevalence of vitamin B 12 deficiency appears to increase with age among the elderly population.4 5 Furthermore, reports have indicated that institutionalised elderly with multiple co-morbidities and with increasing dependency are more prone to vitamin B 12 deficiency than non-institutionalised (free-living) elderly

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Methylmalonic acid is a sensitive biomarker used to diagnose vitamin B12 deficiency, especially in borderline cases

Prioritizing restorative sleep, engaging in cognitive learning activities, and maintaining healthy stress management practices may further help reinforce neural resilience pathways associated with BDNF and synaptic plasticity