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Once the adipose tissue expandability exceeded limit under overnutrition, excess lipids and toxic lipid metabolites (FFA, diacylglycerol, ceramide) accumulated in non-adipose tissues, thus leading to lipid-induced toxicity (lipotoxicity) and developed IR in liver and muscle
Muccioli G et al
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B, JP23H02979, JP23K27670, JP24K02320), and Challenging Research (Exploratory, 20K21627, and 22K19554) by JSPS KAKENHI
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