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An alternative strategy involves engineered probiotics as living nanofactories that secrete GLP-1 analogues directly in the gut [390, 391]

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GLP-1 is responsible for: Stimulating insulin production, which pulls sugar from the blood and carries it to the cells to be used as energy Regulating the appetite and hunger signals Decreasing the release of glucagon to lower blood sugar Controlling the rate at which the stomach empties after eating Medications like Semaglutide perform the same functions as GLP-1

They are approved only for type 2 diabetes and weight management in eligible patients, and are not included in NICE or British Association of Dermatologists guidance for psoriasis

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